Hemoglobinopathies

1. Perrine, SP, Castaneda, SA, Chui, DHK, Faller DV, Berenson,RJ, Siritanaratku,N, and Fucharoen, S: Fetal globin gene inducers: novel agents and new potential Ann. N.Y. Acad. Sci. 2010 1202 158–164
2. Bohacek R, Boosalis MS, McMartin C., Faller DV and Perrine SP: Identification of novel small molecule inducers of fetal hemoglobin using pharmacophore and “pseudo” receptor models. 2006, Chem Biol Drug Des., 67:318-28.
3. Mankidy R, Faller, DV, Bohacek R and Perrine SP: Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. 2006, Blood, 108:3179-186.
4. Casteneda S, Boosalis MS, Emery D, Thies A, Faller DV and Perrine SP: Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives. 2005, Blood Cells, Mol, and Dis., 35:217-26.
5. Perrine SP: Fetal globin induction - Can it cure beta thalassemia? 2005. American Society of Hematology Educational Program, pp. 38-44.
6. Perrine SP, Castenada SA, Boosalis MS, White GL, Jones MB and Bohacek R: Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress. 2005, Ann N Y Acad Sci., 1054:257-65.
7. Weinberg RS, Ji X, Sutton M, Perrine S, Galperin Y, Li Q, Liebhaber SA, Stamatoyannopoulos G and Atweh GF: Butyrate increases the efficiency of translation of gamma-globin mRNA. 2005, Blood 105:1807-1809.
8. Pace BS, White, GL, Dover GJ, Boosalis MS, Faller, DV and Perrine SP: Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. 2002, Blood, 100:4640-4648.
9. Boosalis M, Bandyopadhyay R, Faller, DV and Perrine SP: Short-chain fatty acid derivatives stimulate cell proliferation and induce Stat5 activation. 2001, Blood, 97:3259-3267.
10. Steinberg MH, Rodgers GP: Pharmacologic Modulation of Fetal Hemoglobin. 2001, Medicine, 80:328-344.
11. Atweh GF, Sutton M, Nassif I, Boosalis V., Dover GJ, Wright E, McMahon L, Stamatoyannopoulos G, Faller, DV, and Perrine SP: Sustained induction of fetal hemoglobin by pulsing butyrate therapy in sickle cell disease. 1999, Blood, 93:1790-1797.
12. Ikuta T, Atweh G, Boosalis V, White GL, DA Fonseca S, Boosali M, Faller DV and Perrine SP: Cellular and molecular effects of pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis. 1998, Ann N Y Acad Sci., 850:87-99.
13. Perrine SP, Ginder G., Faller DV, Kan YW, Jin XX and Olivieri NF: A short-term trial of butyrate to stimulate fetal globin gene expression in the beta globin gene disorders. 1993, New Engl J Med., 328:81-86.
14. Perrine, SP, Rudolph A, Faller DV, Roman C, Cohen, RA, Chen, SJ, and Kan YW: Butyrate infusions in the ovine fetal delay the biologic clock for globin gene switching. 1988, Proc. Natl Acad Sci., USA, 85:8540-8542.
15. Perrine SP, Greene MF and Faller DV: Delay in the fetal globin switch in infants of diabetic mothers. New Engl J Med., 1985, 312:334-338.
16. Perrine SP, et al: Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose and Repeat-Dose Studies in Healthy Volunteers. J Clin Pharmacol published online 21 March 2011. DOI: 10.1177/0091270010379810.
17. Fuchareon S, HQK-1001 is Well Tolerated and Augments Hemoglobin F and Hemoglobin Levels in Patients with Beta Thalassemia Intermedia, 2011 ASH poster

Epstein-Barr Viral Malignancies

1. Ghosh SK, Forman LW, Akinsheye I, Perrine SP and Faller DV: Short discontinuous sodium butyrate exposure efficiently sensitizes latently EBV infected cells towards nucleoside analogue-mediated growth inhibition. 2007, Blood Cell Mol Diseases, 38(1):57-65.
2. Perrine SP, Hermine O, Small T, Suarez F, O'Reilly R, Boulad F, Fingeroth J, Askin M, Mentzer SJ, Levy A, DiNicola M, Klein C, Horwitz S and Faller DV: A Phase I/II study of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. 2007, Blood, 109:2571-2578.
3. Faller, DV Mentzer SJ., and Perrine SP: Induction of the Epstein-Barr Virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for EBV-associated malignancies. 2001, Curr Opin Oncol., 13:360-367.
4. Mentzer SJ, Perrine, SP and Faller DV: Epstein-Barr Virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with Arginine Butyrate. 2001, Transplant Infect Dis., 3:177-185.
5. Mentzer SJ, Fingeroth J, Reilly JJ, Perrine SP et al. Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr virus (EBV)-associated lymphoma. 1998, Blood Cells Molecules.Dis., 24:114-23.